How Compounds Work – Lipoderm
The key in transdermal delivery of drugs is finding a vehicle that is able to solubilize drugs, and still possess the capacity to allow transdermal delivery. The advantage of Lipoderm is its constituents combine several entities, which allow for maximal solubilization of drugs, and maximal delivery of the drug through the skin. Lipoderm allows for disorganization of the skins structure, while leaving the skin intact and unharmed. Another advantage is Lipoderm’s absorption rate through the skin that it is slower while tissue levels remain higher for longer periods. The skin acts as drug reservoir, which allows for a slow release of drug from the subcutaneous tissue and allows for a longer duration of action oppose to oral administration. The combination of the ingredients in the compound cream can attack the cause of pain at the site of injury, and / or block pain perception at the spinal cord level.
Possible Side Effects
Studies have shown that side effects are generally non-existent, even with repeated use due to the fact that the compound creams are not significantly absorbed into the bloodstream. The most commonly reported side effects are rash, irritation, or photosensitivity at the application site. If side effects do occur, try using less product, or applying it less frequently. Patients usually find they can lower their dose of other pain medication once the cream starts working.
Application of the Creams
Apply the compound cream to the affected area, in a thin smooth layer, 3-4 times daily for the first few days to minimize pain and 2-3 times daily thereafter. Massage compound cream into the affected area(s) for about 60 seconds. Cream should not be used on skin that is irritated, peeling, infected or on open wounds.